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Robert J Fram Selected Research

XMT 1001

5/2012Pharmacokinetics and antitumor efficacy of XMT-1001, a novel, polymeric topoisomerase I inhibitor, in mice bearing HT-29 human colon carcinoma xenografts.
11/2009XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer.

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Robert J Fram Research Topics

Disease

4Neoplasms (Cancer)
05/2012 - 11/2005
3Myelodysplastic Syndromes (Myelodysplastic Syndrome)
01/2023 - 01/2018
2Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
01/2022 - 01/2018
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2022 - 01/2018
2Fatigue
07/2021 - 11/2005
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2024
1Anemia
07/2021
1Carcinoma (Carcinomatosis)
05/2012
1Edema (Dropsy)
11/2005
1Melanoma (Melanoma, Malignant)
11/2005
1Alopecia (Baldness)
11/2005
1Nausea
11/2005
1Neutropenia
11/2005
1Peripheral Nervous System Diseases (PNS Diseases)
11/2005
1Ileus
11/2005

Drug/Important Bio-Agent (IBA)

22- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
05/2012 - 11/2009
2XMT 1001IBA
05/2012 - 11/2009
2Irinotecan (Camptosar)FDA LinkGeneric
05/2012 - 11/2009
2CamptothecinIBA
05/2012 - 11/2009
2tasidotinIBA
11/2005 - 11/2005
1ErbB Receptors (EGF Receptor)IBA
01/2024
1Azacitidine (5 Azacytidine)FDA Link
01/2022
1pevonedistatIBA
01/2022
1SolutionsIBA
07/2021
1Topoisomerase I InhibitorsIBA
05/2012
1ProdrugsIBA
11/2009
1Aspartic Acid (Aspartate)FDA Link
11/2005
1Transaminases (Aminotransferases)IBA
11/2005
1Alanine Transaminase (SGPT)IBA
11/2005

Therapy/Procedure

2Drug Therapy (Chemotherapy)
01/2018 - 01/2018
1Therapeutics
01/2023
1Hematopoietic Stem Cell Transplantation
01/2018